منابع مشابه
Long Noncoding RNAs
Ma Recent studies suggest that the majority of the human genome is transcribed, but only about 2% accounts for proteincoding exons. Long noncoding RNAs (lncRNAs) constitute a heterogenic class of RNAs that includes, for example, intergenic lncRNAs, antisense transcripts, and enhancer RNAs. Moreover, alternative splicing can lead to the formation of circular RNAs. In support of putative function...
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Aging is associated with increasing the risk of disease and death. Recently, increasing evidences suggest that many long noncoding RNAs (lncRNAs) function through specific interactions with other cellular factors, namely proteins, DNA, and other RNA molecules. LncRNAs play important roles in a wide range of age-related diseases, such as cancer, cardiovascular pathologies, and neurodegenerative ...
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Mammalian development is under tight control to ensure precise gene expression. Recent studies reveal a new layer of regulation of gene expression mediated by long noncoding RNAs. These transcripts are longer than 200nt that do not have functional protein coding capacity. Interestingly, many of these long noncoding RNAs are expressed with high specificity in different types of cells, tissues, a...
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In this issue of Blood, Alvarez-Dominguez et al use a combination of genomics technology, bioinformatics, and functional analyses to provide new insights into our understanding of the role of long noncoding RNAs (lncRNAs) in erythropoiesis.1 This is an initial step forward in our understanding of the many roles of lncRNAs in normal and perturbed erythropoiesis. lncRNAs have recently emerged as ...
متن کاملLong noncoding RNAs regulate adipogenesis.
The prevalence of obesity has led to a surge of interest in understanding the detailed mechanisms underlying adipocyte development. Many protein-coding genes, mRNAs, and microRNAs have been implicated in adipocyte development, but the global expression patterns and functional contributions of long noncoding RNA (lncRNA) during adipogenesis have not been explored. Here we profiled the transcript...
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ژورنال
عنوان ژورنال: WIREs RNA
سال: 2021
ISSN: 1757-7004,1757-7012
DOI: 10.1002/wrna.1664